A variety of conditions, resulting from the deficiency of plasminogen, necessitate multi-disciplinary, coordinated care for these patients.
Patients’ wound-healing capability is severely reduced and is often obvious in mucous membranes (e.g., conjunctivae) where plasminogen plays a crucial role in intravascular and extravascular fibrinolysis.1
Ligneous conjunctivitis, characterized by thick, woody (ligneous) growths on the conjunctiva of the eye (Figure 2), is the main manifestation (80% of cases) of hypoplasminogenemia (type I). It first appears with erythema of the conjunctivae and chronic tearing followed by the formation of pseudomembranes (yellow-white or thick red masses with a wood-like consistency) on the palpebral surfaces. Pseudomembrane development is often the result of mechanical injury to the conjunctival mucosa relating to infection, trauma, or surgery. If left untreated,