Coordinate with a Hematologist
Coordinate with a Hematologist

Ligneous Conjunctivitis
reveals Plasminogen
deficiency Type 1 (plgd-1)1

Symptoms & Signs Available Treatment Real patient stories
Ligneous conjunctivitis animation

PLGD-1 is
characterized
by lesions with a
woody texture1

Symptoms & Signs Available Treatment Real patient stories

87% of patients with PLGD-1 present with ligneous conjunctivitis (LC)2*

87% of patients with PLGD-1 present with ligneous conjunctivitis (LC)

*Patient pool of 102 individuals with a mean age at onset of 5 years and 5 months and a consanguinity rate of 40%.

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Illustration representing how plasminogen deficiency often presents as woody growths on the mucous membranes

LC is the most common manifestation of PLGD-1, a systemic disease caused by low levels of functional plasminogen.1

Lesions can form on mucous membranes throughout the body, both internally and externally.1

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Among those with ligneous conjunctivitis

8 of 10 with ligneous conjunctivitis exhibited lesions in other parts of the body

exhibited lesions in other parts of the body2†

†Patient pool primarily originates from Turkey and various Arabian countries (61%). When compared to previously published cases, this group of patients presented at a younger mean age (1 year and 10 months old) and shows a high rate of consanguinity (61%).

Amy and Ryan thumbnail

What is plasminogen deficiency type 1?

PLGD-1 is a systemic protein deficiency. Individuals with PLGD-1 have both abnormally low plasminogen levels and reduced plasminogen activity, resulting in the formation of fibrin-rich lesions on mucous membranes throughout the body.4 Symptoms of PLGD-1 often resemble those of other more common conditions.5 This autosomal recessive disorder occurs when a person has a mutation in both copies of the gene for plasminogen.6

For a while we thought it was pink eye, but we kept going back to the doctor because it wasn't getting better.
Amy & Regan
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Graphic showing CPT code 85420 for plasminogen activity testing

PLGD-1 can be diagnosed with a simple blood test for plasminogen activity1

Undiagnosed patients may be at risk of severe complications from untreated lesions5

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What is plasminogen?

Plasminogen is the inactive precursor of plasmin, an enzyme that plays a key role in the prevention and dissolution of fibrin clots and wound healing.7 Without functional plasminogen, the body is unable to degrade fibrin, which plays a key role in blood clotting.4

Visual representation of the role plasminogen and fibrin play in clot dissolution

Understanding ligneous conjunctivitis

Explore signs and symptoms of the most common manifestation of PLGD-1.

Recognize LC >

References: 1. Mehta R, Shapiro AD. Plasminogen deficiency. Haemophilia. 2008;14(6):1261-1268. 2. Klammt J, Kobelt L, Aktas D, et al. Identification of three novel plasminogen (PLG) gene mutations in a series of 23 patients with low PLG activity. Thromb Haemost. 2011;105(3):454-460. 3. Data on file. Kedrion Biopharma Inc. 4. Schuster V, Hügle B, Tefs K. Plasminogen deficiency. J Thromb Haemost. 2007;5(12):2315-2322. 5. Shapiro AD, Nakar C. How I treat type 1 plasminogen deficiency. Blood. 2025;145(25):2954-2965. 6. Tefs K, Gueorguieva M, Klammt J, et al. Molecular and clinical spectrum of type I plasminogen deficiency: a series of 50 patients. Blood. 2006;108(9):3021-3026. 7. Congenital type 1 plasminogen deficiency. NORD. Updated February 6, 2025. Accessed December 4, 2025. https://rarediseases.org/rare-diseases/congenital-plasminogen-deficiency